PD-321852

SKU: orb1740499

Description

PD-321852 is a selective Chk1 inhibitor that enhances gemcitabine cytotoxicity in pancreatic cancer models, as demonstrated by in vitro studies showing synergistic chemosensitization and loss of Chk1 protein. This compound is a valuable research tool for investigating DNA damage response pathways and combination chemotherapy strategies.

Research Area

Cell Biology

Key Properties

• CAS Number: 622856-21-7
• MW: 468.33
• Formula: C₂₄H₁₉Cl₂N₃O₃
• SMILES: C(CCNC)N1C2=C(C3=C(C(=C2)C4=C(Cl)C=CC=C4Cl)C(=O)NC3=O)C=5C1=CC=C(O)C5
• Target: Chk,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

11612456