PD-1/PD-L1-IN-NP19

SKU: orb1693345

Description

PD-1/PD-L1-IN-NP19 is a potent small molecule inhibitor of the PD-1/PD-L1 immune checkpoint, demonstrating an IC50 of 12.5 nM in biochemical assays. It is a valuable research tool for studying cancer immunotherapy mechanisms, enabling in vitro T-cell activation studies and in vivo investigation of antitumor immune responses in preclinical models.

Research Area

Cancer Biology; Immunology & Inflammation, Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2377916-66-8
• MW: 555.06
• Purity: 96.70% (May vary between batches)
• Formula: C₃₃H₃₁ClN₂O₄
• SMILES: Cc1c(COc2cc(OCc3cccc(c3)C#N)c(CNC(C)(C)C(O)=O)cc2Cl)cccc1-c1ccccc1
• Target: PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

154573771