PD-1/PD-L1-IN-9

SKU: orb1685258

Description

PD-1/PD-L1-IN-9

Research Area

Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2628506-54-5
• MW: 348.44
• Purity: 99.92%
• Formula: C₂₂H₂₄N₂O₂
• SMILES: COc1nc(ccc1CNCCO)-c1cccc(c1C)-c1ccccc1
• Target: PD-1/PD-L1
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.47 mM);DMSO:90 mg/mL (258.29 mM)

Bioactivity

• In Vivo:
  PD-1/PD-L1-IN-9 (40-80 mg/kg; p.o. once a day for 2 weeks) inhibits tumor growth in a dose-dependent manner without causing body weight loss or mortality in mice. PD-1/PD-L1-IN-9 (3 mg/kg; a single i.v.) exhibits a half-life (t1/2=4.2 h), plasma clearance (Cl=11.5 L/h/kg), and Cmax (1233 ng/mL) in rats. PD-1/PD-L1-IN-9 (25 mg/kg; a single p.o.) shows moderate oral bioavailability (F=22%), half-life (t1/2=6.4 h), and Cmax (192 ng/mL) in rats.
• In Vitro:
  PD-1/PD-L1-IN-9 (46.9-1500 nM; pretreated for 2 h) enhances the antitumor immunity of PBMCs against MDB-MB 231 cells in a dose-dependent manner, with an EC50 of approximately 100 nM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PD1/PDL1IN9, PD-1/PD-L1-IN-9, PD1/PDL1, PD-1, PD-1/PD-L1, PD1, PD 1/PD L1 IN 9, PD-L1, PDL1

Compound Identifiers

PubChem CID

155925913