PD-1/PD-L1-IN-62

SKU: orb3211473

Description

PD-1/PD-L1-IN-62 is a PD-L1 inhibitor and mTOR regulator. It inhibits PD-L1 with an IC50 of 6.9 nM and disrupts the PD-1/PD-L1 pathway-mediated immune suppression. By inhibiting mTOR phosphorylation and downregulating downstream target SREBP1, it significantly reduces cholesterol and triglyceride levels to decrease lipid accumulation. Additionally, PD-1/PD-L1-IN-62 enhances the infiltration of CD3+CD8+ T cells into tumor tissue, effectively inhibiting tumor growth. This compound is applicable in hepatocellular carcinoma research.

Key Properties

• Target: PD-1/PD-L1,mTOR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PD-1/PD-L1,mTOR