PD-1/PD-L1-IN-61

SKU: orb3210788

Description

PD-1/PD-L1-IN-61 is an inhibitor of the PD-1/PD-L1 interaction, with an IC50 value of 5.3 nM for human studies. It binds stably within the hydrophobic pocket of the PD-L1 dimer interface through hydrogen bonds and π-π stacking interactions with PD-L1 residues. As an immune activator, PD-1/PD-L1-IN-61 enhances the immune cytotoxicity of peripheral blood mononuclear cells against cancer cells, restores T cell immune function, and promotes IFN-γ secretion. This compound is applicable in research related to triple-negative breast cancer.

Key Properties

• CAS Number: 2983098-90-2
• MW: 776.83
• Formula: C₄₂H₄₄N₆O₉
• SMILES: CC1=C(C=CC=C1C=2OC(CN3CCC(O)CC3)=NN2)C4=C(C)C(COC5=C(N(=O)=O)C=C(CN[C@@H](C(C)O)C(O)=O)C(OCC6=CC(C#N)=CC=C6)=C5)=CC=C4
• Target: PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

PD-1/PD-L1