PD-1/PD-L1-IN-29

SKU: orb1744714

Description

PD-1/PD-L1-IN-29 (S4-1) is a potent small molecule PD-1/PD-L1 interaction inhibitor with an IC50 of 6.1 nM. It induces PD-L1 dimerization and internalization, relocalizing it to the endoplasmic reticulum. This mechanism disrupts the immunosuppressive PD-1/PD-L1 axis, demonstrating anticancer activity in research models for immuno-oncology.

Research Area

Cancer Biology; Immunology & Inflammation, Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2665734-13-2
• MW: 460.48
• Formula: C₂₆H₂₄N₂O₆
• SMILES: O=C1N(C(=O)C=2C1=CC(CN[C@H](C(O)=O)CO)=C(OC)C2)C3=C(C)C(=CC=C3)C4=CC=CC=C4
• Target: PD-1/PD-L1,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

166642489