PD-1/PD-L1-IN-27

SKU: orb1744745

Description

PD-1/PD-L1-IN-27 is a small molecule PD-1/PD-L1 interaction inhibitor with an IC50 of 134 nM. It demonstrates antitumor activity by activating CD8+ T cells and reversing T cell exhaustion in research models, while showing minimal cytotoxicity against T cells.

Research Area

Cancer Biology; Immunology & Inflammation, Cell Biology, Immunology & Inflammation

Key Properties

• CAS Number: 2891831-47-1
• MW: 673.75
• Formula: C₄₄H₃₅NO₆
• SMILES: CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C=C3)CN4CC5=CC=CC=C5C[C@@H]4C(=O)O)OC6=CC(=O)OC7=C6C=CC8=CC=CC=C87
• Target: PD-1/PD-L1

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163322388