PD 151746

SKU: orb1305399

Description

PD 151746

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 179461-52-0
• MW: 237.25
• Purity: 98.63%
• Formula: C₁₁H₈FNO₂S
• SMILES: OC(=O)C(S)=Cc1c[nH]c2ccc(F)cc12
• Target: Proteasome,Cysteine Protease
• Solubility: Ethanol:44 mg/mL (185.46 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:44 mg/mL (185.46 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.43 mM)

Bioactivity

• Target IC50:
  m-Calpain:5.33 μM|μ-Calpain:260 nM
• In Vivo:
  PD151746 reduces the cytotoxicity induced by oxidized low-density lipoprotein (oxLDL) in HMEC-1 cells. It also effectively mitigates the hydrolysis of SLLVY-AMC induced by marine toxins in SY5Y cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CysteineProtease, Cysteine Protease, PD151746, PD-151746, PD 151746, m-calpain, Proteasome, μ-Calpain

Compound Identifiers

PubChem CID

4704