PD 128042

SKU: orb1305858

Description

PD 128042 (CI 976) is a potent, orally bioavailable small molecule that selectively inhibits ACAT (IC50: 73 nM) and Golgi-associated lysophospholipid acyltransferase (LPAT; IC50: 15 µM). This dual activity disrupts intracellular lipid metabolism and membrane trafficking, making it a valuable research tool for studying atherosclerosis, lipid storage diseases, and vesicular transport in cellular models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 114289-47-3
• MW: 393.56
• Purity: 99.79% (May vary between batches)
• Formula: C₂₃H₃₉NO₄
• SMILES: CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)cc(OC)cc1OC
• Target: Acyltransferase
• Solubility: Ethanol:25 mg/mL (63.52 mM);DMF:25 mg/mL (63.52 mM);DMSO:25 mg/mL (63.52 mM)

Bioactivity

• Target IC50:
  Golgi-associated LPAT:15 μM|ACAT:73 nM
• In Vitro:
  In the chronic cholesterol-fed rat model, CI 976 decreases non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol in rats with pre-established dyslipidemia.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CI976, CI-976, CI 976, Diglyceride acyltransferase, Diacylglycerol acyltransferase, ACAT, acyl-CoA:cholesterol acyltransferase, Acyltransferase, LPAT, inhibit, PD 128042, PD128042, PD-128042, oral, mono- acylglycerol acyltransferase, Inhibitor, endocytic membrane trafficking pathway, secretory, transferase

Compound Identifiers

PubChem CID

122327