PD-089828

SKU: orb1298477

Description

PD 089828 is a potent small molecule inhibitor targeting key tyrosine kinases. It acts as a competitive inhibitor of FGFR1, PDGFRβ, and EGFR, and a noncompetitive inhibitor of c-Src. This compound is a valuable research tool for studying kinase signaling in cancer and angiogenesis, applicable in both cellular and biochemical assays.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 179343-17-0
• MW: 405.28
• Purity: 97.39%
• Formula: C₁₈H₁₈Cl₂N₆O
• SMILES: CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1c(Cl)cccc1Cl
• Target: EGFR,FGFR,PDGFR,Src
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  EGFR:5.47 µM|c-Src:0.18 μM|c-Src:0.1 μM (Ki)|FGFR1:0.15 µM|PDGFRβ:1.76 µM
• In Vitro:
  PD 089828 as a novel, broadly active protein tyrosine kinase inhibitor with long-lasting but reversible cellular effects. The potential therapeutic use of these broadly acting, nonselective inhibitors as antiproliferative and antimigratory agents could extend to such diseases as cancer, atherosclerosis and restenosis in which redundancies in growth-signaling pathways are known to exist.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Src, smooth, Platelet-derived growth factor receptor, PDGFR, PDGFRβ, phosphorylation, vascular, PD089828, PD-089828, PD 089828, muscle, nonselective, inhibit, Inhibitor, HER1, EGFR, Epidermal growth factor receptor, Fibroblast growth factor receptor, FGFR1, FGFR, ErbB-1, cells, competitive, autophosphorylation, ATP, antimigratory, antiproliferative

Compound Identifiers

PubChem CID

5328112