PCNA-I1

SKU: orb1298495

Description

PCNA-I1 is a small molecule inhibitor that disrupts the association of proliferating cell nuclear antigen (PCNA) with chromatin. It is a research tool used in vitro and in vivo to study DNA replication and repair mechanisms in prostate cancer and other oncology fields.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 444930-42-1
• MW: 310.37
• Purity: 97.64% (May vary between batches)
• Formula: C₁₇H₁₄N₂O₂S
• SMILES: Cc1ccsc1C(=O)N\N=C\c1ccc2ccccc2c1O
• Target: Others
• Solubility: DMSO:3.11 mg/mL (10.02 mM)

Bioactivity

• In Vivo:
  Intravenous administrations of PCNA-I1 significantly retarded growth of LNCaP tumors of in nude mice without causing detectable effects on mouse body weight and hematology profiles.
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• In Vitro:
  PCNA-I1 induced DNA damage and apoptosis in both LNCaP and PC-3 cells and enhanced DNA damage and apoptosis triggered by cisplatin. PCNA-I1 also induced autophagy in PC-3 cells. A short-term pretreatment with PCNA-I1 reduced colony formation by 50% in both cell lines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA/RNA Synthesis, PCNA I1, PCNAI1, PCNA-I1, PCNA-I-1, PCNA, inhibit, Inhibitor

Compound Identifiers

PubChem CID

135533619