PBT-1033

SKU: orb1217676

Description

PBT-1033(PBT-2) is a potential neuroprotective agent for the treatment of Alzheimer's disease and Huntington's disease.

Key Properties

• CAS Number: 747408-78-2
• MW: 271.14
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₂Cl₂N₂O
• SMILES: CN(C)Cc1ccc(c(Cl)cc(Cl)c2O)c2n1
• Target: others
• Solubility: In Vitro: DMSO : 100 mg/mL (368.81 mM)

Bioactivity

• In Vivo:
  PBT 1033 (30 mg/kg/d, p.o. , 11 days) restores biochemical substrates of learning/memory in a mouse model of alzheimer's disease. Animal model: Female Tg2576 mice. Dosage: 30 mg/kg/d. Administration: Oral administration, 11 days. Result: Increased hippocampal apical spine density, basal spine density.
• In Vitro:
  PB 1033 displays antibacterial activity against S. uberis, with a MIC value of 14.5 μM. PBT2 (1, 3 and 7.5 μM, 6 h) protects neurons against glutamate-induced excitotoxicity. PBT2 (10 μM, 1 or 6 h) reduces NMDAR-mediated Ca2+ flux in mouse cortical neurons. PBT2 (0-10 μM, 1 h) increases GSK3α/β phosphorylation in SH-SY5Y cells. PBT2 (20 μM, 1 h) prevents the formation of Zn-induced protease resistant Aβ aggregates. Western blot analysis. Cell line: SH-SY5Y cells. Concentration: 0-10 μM. Incubation time: 1 h. Result: Increased in cellular levels of GSK3α/β phosphorylated at the inhibitory serine 21/9 residue (ser21/9 on GSK3α/β).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PB 1033 | PBT-2 | PBT1033 | PBT2 | PBT 1033 | PBT 2

Quick Database Links

Gene Symbol

others