PBRM1-BD2-IN-7

SKU: orb1689802

Description

PBRM1-BD2-IN-7 is a potent and selective cell-permeable inhibitor of the PBRM1 bromodomain 2 (BD2) with an IC50 of 0.29 µM. This tool compound is used in cancer research to probe PBRM1's role in chromatin remodeling and gene regulation in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2819989-68-7
• MW: 286.76
• Purity: 99.86% (May vary between batches)
• Formula: C₁₆H₁₅ClN₂O
• SMILES: O=C1C=2C(NC(N1)C3=C(C)C=CC=C3C)=CC=CC2Cl
• Target: Epigenetic Reader Domain
• Solubility: DMSO:55 mg/mL (191.8 mM)

Bioactivity

• In Vitro:
  PBRM1-BD2-IN-7 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibits the growth of a PBRM1-dependent prostate cancer cell line, with an IC50 value of 0.29 μM for PBRM1-BD2 inhibitory activity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EpigeneticReaderDomain, Epigenetic Reader Domain, PBRM1BD2IN7, PBRM1-BD2-IN-7

Compound Identifiers

PubChem CID

164880779