PBRM1-BD2-IN-5

SKU: orb1689798

Description

PBRM1-BD2-IN-5 is a potent and selective small molecule inhibitor of the PBRM1 bromodomain 2 (BD2), with a Kd of 1.5 µM and an IC50 of 0.26 µM. It disrupts PBAF complex interactions with acetylated histones in cellular assays, making it a valuable chemical probe for oncology research targeting chromatin remodeling in cancer.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2819989-61-0
• MW: 272.73
• Purity: 99.55% (May vary between batches)
• Formula: C₁₅H₁₃ClN₂O
• SMILES: O=C1C=2C(NC(N1)C3=CC(C)=CC=C3)=CC=CC2Cl
• Target: Epigenetic Reader Domain
• Solubility: DMSO:50 mg/mL (183.33 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.33 mM)

Bioactivity

• In Vitro:
  PBRM1-BD2-IN-5 (compound 16) (0-10 μM; 5 days) inhibits PBRM1-expressed LNCaP cells and reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptides.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EpigeneticReaderDomain, Epigenetic Reader Domain, PBRM1BD2IN5, PBRM1-BD2-IN-5

Compound Identifiers

PubChem CID

164880770