PBOX 6

SKU: orb1706844

Description

PBOX 6 is a pyrrolo-1,5-benzoxazepine compound exhibiting anticancer activity. It inhibits breast cancer cell proliferation in vitro and induces apoptosis in leukemia cells by JNK-mediated phosphorylation and inactivation of Bcl-2/Bcl-XL. Its research applications include studying apoptosis mechanisms and oncogenic signaling pathways in various cancer models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 290814-68-5
• MW: 396.44
• Purity: 99.98% (May vary between batches)
• Formula: C₂₅H₂₀N₂O₃
• SMILES: CN(C)C(=O)OC1=C(Oc2ccccc2-n2cccc12)c1cccc2ccccc12
• Target: Microtubule Associated,Apoptosis
• Solubility: DMSO:30 mg/mL (75.67 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.04 mM)

Bioactivity

• In Vitro:
  PBOX 6, a potent apoptotic PBOX, does not elicit a general toxic effect in a rat R2C Leydig cell line. Treatment with PBOX 6 (0-25 μM, 16 h) induces dose- and time-dependent apoptosis and causes DNA fragmentation at 10 μM in HL-60 cells. Additionally, PBOX 6 (10 μM) induces apoptosis through the activation of caspase 3-like proteases in HL-60 cells. The apoptotic induction by PBOX 6 (10 μM) also leads to the accumulation of cytochrome c in the cytosol, independent of oxidative stress, peripheral-type benzodiazepine receptor (PBR), and NF-κB. In MCF-7 cells, PBOX 6 (25 μM) induces apoptosis through the activation of caspase-7. Furthermore, in K562 cells, PBOX 6 (10 μM) induces the redistribution of cypA from the nucleus to the cytosol and nucleocytoplasmic redistribution of cypA and pin1 through a JNK-dependent manner. This effect is also dependent on upstream activation of a trypsin-like serine protease, correlating with G2/M arrest.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, PBOX 6, PBOX6, PBOX-6

Compound Identifiers

PubChem CID

9865511