PBD dimer-4

SKU: orb3135895

Description

PBD dimer-4 (Compound 7) is a C1-substituted PBD dimer. This compound exhibits high DNA-binding affinity, effective DNA cross-linking ability, and potent cytotoxicity against MDA-MB-231 cells (IC50: 236 nM). PBD dimer-4 serves as a payload in the ADC drug Loncastuximab tesirine, utilized for treating various cancer types.

Research Area

Molecular Biology

Key Properties

• CAS Number: 1821339-88-1
• MW: 592.64
• Formula: C₃₁H₃₆N₄O₈
• SMILES: O(CCCO[C@@H]1[C@@]2(N(CC1)C(=O)C=3C(N=C2)=CC(OC)=C(OC)C3)[H])[C@@H]4[C@@]5(N(C(=O)C=6C(N=C5)=CC(OC)=C(OC)C6)CC4)[H]
• Target: DNA Alkylator/Crosslinker,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

DNA Alkylator/Crosslinker,Others