PBA-1105 TFA

SKU: orb2945002

Description

PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. This compound selectively binds to the exposed hydrophobic regions of misfolded proteins, promoting their degradation through the autophagy (autophagy) pathway. Additionally, PBA-1105 TFA enhances the autophagic flux of Ub-bound aggregates.

Key Properties

• MW: 754.832
• Formula: C₄₁H₄₉F₃N₂O₈
• SMILES: C1=CC=C(C=C1)CCCC(=O)NCCOCCOCCOCCNCC2=CC(=C(C=C2)OCC3=CC=CC=C3)OCC4=CC=CC=C4.C(=O)(C(F)(F)F)O
• Target: Autophagy,AUTACs

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Autophagy,AUTACs