PB2-IN-2

SKU: orb3174915

Description

PB2-IN-2 is an orally active PB2 inhibitor with RNP inhibitory activity (IC50) of 0.2 nM, cellular level replication inhibition activity (LRAEC50) of 0.8 nM, and cytopathic effect inhibition activity (CPEEC50) of 0.1 nM. It demonstrates nanomolar range broad-spectrum antiviral efficacy against various influenza A strains, including H1N1pdm09, Lyon/1337/2007/H1N1, Tex12-Like/H3N2, PR/8/34/H1N1, WSN/1933/H1N1, and rPR8(H1N1)/H7N9, with EC50 values of 1.5, 3.6, 3.7, 13.8, 2.9, and 9.8 nM, respectively, and CC50 values all greater than 2 μM. PB2-IN-2 also shows excellent metabolic stability and pharmacokinetic properties, making it suitable for influenza research.

Research Area

Infectious Disease & Virology

Key Properties

• Target: Influenza Virus

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Influenza Virus