PAWI-2

SKU: orb2646204

Description

PAWI-2 is a multi-targeting small molecule that activates p53 and inhibits Wnt/β-catenin and TBK1 phosphorylation, inducing apoptosis and cell cycle arrest. It reverses stemness and drug resistance in KRAS-dependent pancreatic cancer stem cells, demonstrating efficacy in both in vitro assays and in vivo orthotopic xenograft models.

Research Area

Cell Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1448427-02-8
• MW: 371.45
• Formula: C₁₉H₂₁N₃O₃S
• SMILES: O=C1N(C2=CC=C(C=C2)S(=O)(=O)N3C=4C=CC=CC4N(C)CC3)CCC1
• Target: Wnt/beta-catenin,IκB/IKK,MDM-2/p53,Ras,Apoptosis,Caspase,Kras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

89699521