PAWI-2

SKU: orb2646204

Description

PAWI-2 functions as both a p53 activator and a Wnt inhibitor. It suppresses β3-KRAS signaling independently of KRAS and selectively inhibits the phosphorylation of TBK1. Additionally, PAWI-2 triggers apoptosis (activation of caspase-3/7) and induces PARP cleavage. It facilitates the translocation of retinoblastoma protein into the nucleus, leading to G2/M cell cycle arrest. PAWI-2 reverses the cancer stem cell-like properties of KRAS-dependent human pancreatic cancer stem cells (hPCSC) and overcomes drug resistance. Moreover, it inhibits the growth of hPCSC tumors in an orthotopic xenograft mouse model.

Key Properties

• CAS Number: 1448427-02-8
• MW: 371.45
• Formula: C₁₉H₂₁N₃O₃S
• SMILES: O=C1N(C2=CC=C(C=C2)S(=O)(=O)N3C=4C=CC=CC4N(C)CC3)CCC1
• Target: Caspase,IκB/IKK,Ras,Wnt/beta-catenin,Apoptosis,MDM-2/p53,Kras

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Caspase,IκB/IKK,Ras,Wnt/beta-catenin,Apoptosis,MDM-2/p53,Kras