Patchouli alcohol

SKU: orb1304847

Description

Patchouli alcohol (Patchoulol) is a tricyclic sesquiterpenoid and the primary bioactive constituent of patchouli oil. It exhibits diverse pharmacological activities, including anti-inflammatory, antioxidant, and antitumor effects, making it a compound of interest for in vitro and in vivo research in immunology and oncology.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 5986-55-0
• MW: 222.37
• Purity: 99.80% (May vary between batches)
• Formula: C₁₅H₂₆O
• SMILES: [H][C@@]12CC[C@@]3(C)[C@]([H])(C1)[C@@H](C)CC[C@@]3(O)C2(C)C
• Target: Antibacterial,Antifungal
• Solubility: Ethanol:15 mg/mL (67.46 mM);DMSO:45 mg/mL (202.37 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (22.49 mM)

Bioactivity

• In Vivo:
  METHODS: To study the effect on H. pylori-associated gastritis, Patchouli alcohol (5-20 mg/kg) was administered orally to H. pylori-infected mice once daily for two weeks. RESULTS: Patchouli alcohol treatment increased SH-NP content and CAT activity, and significantly protected the gastric mucosa from H. pylori-induced damage.
• In Vitro:
  METHODS: H. pylori-infected GES-1 cells were treated with Patchouli alcohol (5-20 µg/mL) for 24 h. Apoptosis was detected by flow cytometry. RESULTS: Patchouli alcohol treatment significantly reduced H. pylori-induced apoptosis. METHODS: H. pylori-infected GES-1 cells were treated with Patchouli alcohol (5-20 µg/mL) for 24 h, and cytokine levels were measured by ELISA. RESULTS: 5-20 µg/mL Patchouli alcohol treatment significantly reduced the production of TNF-α and MCP-1.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, antifungal, (-)-Patchouli Alcohol, Inhibitor, inhibit, Patchouli alcohol, Patchouli camphor, Patchoulol

Compound Identifiers

PubChem CID

3080622