Pasireotide Acetate

SKU: orb1218069

Description

Pasireotide Acetate is a stable cyclohexapeptide somatostatin mimic.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 396091-76-2
• MW: 1107.26
• Purity: >98% (HPLC)
• Formula: C₆₀H₇₀N₁₀O₁₁
• SMILES: NCCCC[C@@]([H])(/C(O)=N/[C@@]([H])(CC1=CC=C(C=C1)OCC2=CC=CC=C2)/C(O)=N/[C@]3(CC4=CC=CC=C4)[H])/N=C([C@@]([H])(CC5=CNC6=CC=CC=C56)/N=C([C@]([H])(C7=CC=CC=C7)/N=C([C@@]8(C[C@]([H])(CN8C3=O)O/C(O)=N/CCN)[H])\O)\O)\O.CC(O)=O
• Target: Others
• Solubility: DMSO:Soluble

Bioactivity

• In Vivo:
  Animal model: 12 month-old conditional Men1 knockout mice with insulinoma. Dosage: 160 mg/kg/mouth. Administration: S. c. every month for 4 months. Result: Decreased the serum insulin from 1.060 μg/L to 0.3653 μg/L and increased the serum glucose from 4.246 mM to 7.122 mM. Significantly reduced the tumor size and increased apoptosis.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others