PARP/PI3K-IN-1

SKU: orb1708939

Description

PARP/PI3K-IN-1

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2337386-47-5
• MW: 660.62
• Purity: 99.59%
• Formula: C₃₃H₂₈F₄N₈O₃
• SMILES: O=C1NN=C(C=2C=CC=CC12)CC3=CC=C(F)C(=C3)C(=O)N4CC5=NC(=NC(=C5CC4)N6CCOCC6)C7=CN=C(N)C=C7C(F)(F)F
• Target: Apoptosis,PARP,PI3K
• Solubility: DMSO:80 mg/mL (121.1 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5 mM)

Bioactivity

• Target IC50:
  PI3Kα:8.25 (pIC50)|PI3Kβ:6.54 (pIC50)|PARP2:8.44 (pIC50)|PI3Kγ:6.08 (pIC50)|PARP1:8.22 (pIC50)|PI3Kδ:8.13 (pIC50)
• In Vivo:
  PARP/PI3K-IN-1 (IP; 50 mg/kg; treatment for 34 days) significantly inhibits tumor growth.
• In Vitro:
  PARP/PI3K-IN-1 (1 μM; 72 h) decreased the levels of self-phosphorylation of AKT and S6, while increasing the phosphorylation levels of ERK following treatment, indicating the inhibition of the PI3K pathway and activation of the ERK pathway by PARP/PI3K-IN-1, resulting in significantly increased apoptosis.. In BRCA-deficient cells, PARP/PI3K-IN-1 not only exhibits significant inhibitory activity against HCC1937 and HCT116, but also demonstrates anti-proliferative activity against MDA-MB-231 and MDA-MB-468 .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP-2, PARP, PARP-1, PARP/PI3K IN 1, PARP/PI3KIN1, PARP/PI-3K-IN-1, PARP/PI3K-IN-1, PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, PI3K

Compound Identifiers

PubChem CID

146014481