PARPi-FL

SKU: orb1702972

Description

PARPi-FL is a fluorescent small molecule inhibitor of PARP1 used for research. It enables real-time visualization of PARP1 activity in live cells and has been applied in preclinical in vivo imaging models for glioblastoma and oral cancer studies.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1380359-84-1
• MW: 640.46
• Purity: 99.73%
• Formula: C₃₄H₃₂BF₃N₆O₃
• SMILES: O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N+]6[B-](F)(N54)F)=O)=O)=C2)F)C7=C1C=CC=C7
• Target: PARP
• Solubility: DMSO:40 mg/mL (62.46 mM)

Bioactivity

• In Vivo:
  PARPi-FL has a half-life of 24.5 minutes t1/2 in mice. PARPi-FL (2.5 mg/kg) 90 minutes after intravenous administration, the concentration of PARPi-FL in tumors was significantly higher than in muscle or brain, indicating that PARPi-FL was able to generate high-contrast images of tumor tissue in the brain. PARPi-FL can be used for fluorescent-guided tumor resection in a mouse model of oral cancer.
• In Vitro:
  The IC50 of PARPi-FL for glioblastoma cell lines U87 and U251 was 27.7 ± 1.3 μM and 8.0 ± 1.2 μM, respectively.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Olaparib bodipy FL, Olaparib-bodipy FL, PARPi FL, PARPiFL, PARPi-FL

Compound Identifiers

PubChem CID

70697686