PARP1/2/TNKS1/2-IN-1

SKU: orb1744903

Description

This small molecule is a multi-target inhibitor of PARP-1, PARP-2, TNKS1, and TNKS2. It exhibits potential anti-tumor activity by inducing apoptosis, making it a useful research tool for studying DNA damage response and Wnt signaling in cancer models, both in vitro and in vivo.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2243453-32-7
• MW: 634.66
• Purity: 99.63%
• Formula: C₃₅H₃₁FN₆O₅
• SMILES: COC1=CC=C(NC(C2=CC=C(NC(N3CCN(CC3)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O)=O)C=C2)=O)C=C1
• Target: Apoptosis,Wnt/beta-catenin,PARP

Bioactivity

• Target IC50:
  PARP2:1.2 nM|TNKS1:13.5 nM|PARP1:0.25 nM|TNKS2:4.15 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, Wnt, TNKS1, TNKS2, βcatenin, PARP2, PARP1, beta-catenin, betacatenin, bcatenin, Apoptosis

Compound Identifiers

PubChem CID

168277795