PARP10-IN-3

SKU: orb1741341

Description

PARP10-IN-3 is a potent, selective inhibitor of mono-ADP-ribosyltransferase PARP10 (IC50: 480 nM), with additional activity against PARP2 and PARP15. This small molecule tool compound is valuable for investigating PARP10's roles in cellular processes such as DNA damage response, viral replication, and cancer biology in vitro.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2225800-19-9
• MW: 256.26
• Purity: 99.54% (May vary between batches)
• Formula: C₁₄H₁₂N₂O₃
• SMILES: O(C1=CC(C(N)=O)=CC=C1)C2=CC=C(C(N)=O)C=C2
• Target: PARP
• Solubility: DMSO:9 mg/mL (35.12 mM)

Bioactivity

• Target IC50:
  PARP4 (human):7 μM|TNKS2 (human):6.5 μM|PARP16 (human):>10 μM|PARP15 (human):1.7 μM|PARP14 (human):41 μM|PARP10 (human):480 nM|PARP2 (human):1.7 μM|PARP12 (human):>10 μM|PARP1 (human):>100 μM|PARP3 (human):>100 μM|TNKS1(human):21 μM
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• In Vitro:
  PARP10-IN-3 exhibits an IC50 of 1-2 μM in HeLa-PARP10 cells as determined by colony formation assay (CFA).

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP10, PARP10IN3, PARP10-IN-3

Compound Identifiers

PubChem CID

69845715