PARP10-IN-2

SKU: orb1744502

Description

PARP10-IN-2 is a potent small molecule inhibitor of mono-ADP-ribosyltransferase PARP10 (IC50=3.64 µM), with additional activity against PARP15 and PARP2. This compound is a valuable chemical probe for studying ADP-ribosylation signaling in cancer and inflammation research, applicable in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 1042780-52-8
• MW: 238.24
• Purity: 99.68%
• Formula: C₁₄H₁₀N₂O₂
• SMILES: O(C1=CC=C(C(N)=O)C=C1)C2=CC=C(C#N)C=C2
• Target: PARP
• Solubility: DMSO:225 mg/mL (944.43 mM)

Bioactivity

• Target IC50:
  TNKS1(human):>100 μM|PARP1 (human):>100 μM|PARP2 (human):27 μM|PARP4 (human):>100 μM|PARP15 (human):11 μM|PARP14 (human):>100 μM|PARP10 (human):3.64 μM|PARP3 (human):>100 μM|TNKS2 (human):>100 μM|PARP16 (human):>10 μM|PARP12 (human):>10 μM
• In Vitro:
  PARP10-IN-2 (Compound 10) has an IC50 of 1-2 μM by clonogenic assay (CFA) in HeLa-PARP10 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP10, PARP15, PARP2

Compound Identifiers

PubChem CID

28825079