PARP1-IN-8

SKU: orb1297823

Description

PARP1-IN-8 is a potent small molecule inhibitor of PARP1 with an IC50 of 97 nM. This compound is a valuable research tool for investigating DNA damage response pathways in oncology research, applicable in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 836640-15-4
• MW: 403.86
• Purity: 99.04%
• Formula: C₂₃H₁₈ClN₃O₂
• SMILES: Clc1cccc(NC(=O)CCn2nc(-c3ccccc3)c3ccccc3c2=O)c1
• Target: PARP
• Solubility: DMSO:1 mg/mL (2.48 mM)

Bioactivity

• Target IC50:
  PARP1:97 nM
• In Vitro:
  PARP1-IN-8 (0, 0.1, 1, 10 μM; 24, 48 h) showed significantly potent anti-proliferative activity against A549 cells and didn’t display any significant cytotoxicity on HFF cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

poly ADP ribose polymerase, phthalazinone, inhibit, PARP1, PARP, Lung adenocarcinoma, N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide, PARP1-IN-8, PARP1IN8 , PARP1 IN 8 , HFF cells, Inhibitor, A549 cells

Compound Identifiers

PubChem CID

3796800