PARP1-IN-5 dihydrochloride

SKU: orb1297984

Description

PARP1-IN-5 dihydrochloride

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2823308-89-8
• MW: 537.46
• Purity: 98.01%
• Formula: C₂₅H₂₆Cl₂N₂O₅S
• SMILES: O=C1C=C(C2=CC=C(O)C=C2)OC3=C(CN4CCN(CC5=CC=CS5)CC4)C(O)=CC(O)=C31.Cl[H].Cl[H]
• Target: PARP
• Solubility: H2O:1 mg/mL (1.86 mM);DMSO:125 mg/mL (232.58 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.44 mM)

Bioactivity

• Target IC50:
  PARP2:0.9 μM|PARP1:14.7 nM
• In Vivo:
  PARP1-IN-5 dihydrochloride (1000 mg/kg; p.o.) shows no significant difference in body weight and blood routine. PARP1-IN-5 dihydrochloride (25 and 50 mg/kg; p.o.; 12 days) significantly enhances the inhibitory effect of carboplatin on A549 cells at 50 mg/kg. PARP1-IN-5 dihydrochloride (50 mg/kg; p.o.) positively correlates with the expression of PARP-1. PARP1-IN-5 dihydrochloride decreases the expression of PAR and upregulates the expression of γ-H2AX .
• In Vitro:
  PARP1-IN-5 dihydrochloride (0.1~320 μM) significantly enhances CBP cytotoxicity on A549 cells in a dose-dependent manner but has minimal cytotoxic effects on A549 cells alone. It also decreases MCM2-7 expression and PAR levels in SK-OV-3 cells and increases γ-H2AX expression, exhibiting antitumor effects via PARP-1.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP2, PARP1-IN-5 Dihydrochloride, PARP1IN5 dihydrochloride , PARP1-IN-5, PARP-1-IN-5 (dihydrochloride), PARP1 IN 5 dihydrochloride , PARP1

Compound Identifiers

PubChem CID

162370708