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PARP1-IN-49

SKU: orb3173889

Description

PARP1-IN-49 is a selective inhibitor of PARP1 with an IC50 value of 23.56 nM and a Kd of 17.78 nM. It exhibits higher selectivity for PARP1 over PARP2. By inhibiting PARP1, PARP1-IN-49 induces DNA damage, cell cycle arrest, and apoptosis (apoptosis). Additionally, it increases intracellular reactive oxygen species (ROS) levels and inhibits cell migration. This compound is applicable in breast and ovarian cancer research.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology

Images & Validation

Key Properties

TargetApoptosis,DNA/RNA Synthesis,ROS,PARP

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information