PARP1-IN-35

SKU: orb2945279

Description

PARP1-IN-35 (T26) is a brain-penetrant, orally bioavailable, and highly selective PARP1 inhibitor with an IC50 of 0.2 nM. It demonstrates potent antiproliferative effects in cellular assays and has shown promising in vivo efficacy in preclinical models of BRCA-mutant cancers, supporting its research utility in oncology, particularly for breast cancer.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• MW: 371.435
• Formula: C₂₂H₂₁N₅O
• SMILES: CCC1=CC2=C(C=C(C=N2)CN3CCC(=CC3)C4=NC=C(C=C4)C#N)NC1=O
• Target: PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171484770