PARP1-IN-31

SKU: orb2665177

Description

PARP1-IN-31 (compound 11f) is a potent PARP1 inhibitor (IC₅₀ = 97 nM) suitable for lung adenocarcinoma research. It demonstrates anti-proliferative and pro-apoptotic effects in vitro, such as in A549 cells, by upregulating caspase-3/9. Its application extends to studying DNA damage response and potential combination therapies in cancer models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 684234-60-4
• MW: 407.83
• Purity: 98.99% (May vary between batches)
• Formula: C₂₂H₁₅ClFN₃O₂
• SMILES: O=C(NC1=CC=C(F)C=C1)CN2N=C(C=3C=CC(Cl)=CC3)C=4C=CC=CC4C2=O
• Target: Caspase,PARP,Apoptosis
• Solubility: DMSO:100 mg/mL (245.2 mM)

Bioactivity

• Target IC50:
  PARP-1:97 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

1307180