PARP1-IN-20

SKU: orb2564367

Description

PARP1-IN-20 (19A10) is a potent PARP1 inhibitor with an IC50 of 4.62 nM, yet it displays a significantly weaker PARP-trapping activity compared to Veliparib (IC50 >100 µM in MDA-MB-436 cells). This profile makes it a useful chemical tool for studying catalytic inhibition in cancer research, applicable in both in vitro and in vivo models of BRCA-deficient cancers.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2659357-95-4
• MW: 539.40
• Formula: C₂₃H₁₉BrN₆O₃S
• SMILES: O=C(N)C=1C=CC=C2N=C(NC21)C=3C=CC(=CC3)C(=O)N4CCN(C(=O)C=5N=C(Br)SC5)CC4
• Target: PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164900108