PARP-2-IN-3

SKU: orb1944810

Description

PARP-2-IN-3 is a potent and selective PARP-2 inhibitor (IC50 = 0.07 µM) with demonstrated anti-tumor activity. It induces apoptosis and necrosis in cancer cells and is a useful chemical probe for breast cancer research, including in vitro cell-based studies. Its CAS number is 128-52-56-8.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2915650-86-9
• MW: 385.84
• Purity: 99.33%
• Formula: C₂₀H₂₀ClN₃O₃
• SMILES: O=C(NC=1C=CC(=CC1)C2=NC3=CC(Cl)=CC=C3O2)CCN4CCOCC4
• Target: Apoptosis,PARP

Bioactivity

• Target IC50:
  PARP2:0.07 μM
• In Vitro:
  PARP-2-IN-3 (Compound 12) proved to be the most active PARP-2 inhibitor with an IC50 value of 0.07 µM, respectively.PARP-2-IN-3 induced cell cycle arrest at G2/M and G1/S phases in a mutant MCF-7 cell line, and possessed significant apoptosis-inducing activity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP2, Apoptosis

Compound Identifiers

PubChem CID

171360922