PARP-1-IN-4

SKU: orb1944629

Description

PARP-1-IN-4 is a potent and selective inhibitor of PARP-1, exhibiting anti-tumor activity in cellular assays. It serves as a valuable chemical probe for researching DNA damage response pathways, with applications in oncology and studies of synthetic lethality in both in vitro and in vivo models.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 684234-56-8
• MW: 424.28
• Purity: 99.82% (May vary between batches)
• Formula: C₂₂H₁₅Cl₂N₃O₂
• SMILES: O=C(NC1=CC=C(Cl)C=C1)CN2N=C(C=3C=CC(Cl)=CC3)C=4C=CC=CC4C2=O
• Target: PARP
• Solubility: DMSO:5 mg/mL (11.78 mM)

Bioactivity

• Target IC50:
  PARP1:302 μM
• In Vitro:
  PARP-1-IN-4 exhibits inhibitory activity against PARP-1, with an IC50 value of 302 μM. It demonstrates cytotoxicity against A549 cells at concentrations of 0.1, 1, and 10 μM for 24h and 48h. Treatment with PARP-1-IN-4 at 1 μM for 24h significantly increases the expression levels of caspase-3 and caspase-9 proteins.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP1

Compound Identifiers

PubChem CID

1830002