PARP-1-IN-4

SKU: orb1944629

Description

PARP-1-IN-4 is a potent and selective inhibitor of PARP-1, exhibiting anti-tumor activity in cellular assays. It serves as a valuable chemical probe for researching DNA damage response pathways, with applications in oncology and studies of synthetic lethality in both in vitro and in vivo models.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 684234-56-8
• MW: 424.28
• Purity: 99.82% (May vary between batches)
• Formula: C₂₂H₁₅Cl₂N₃O₂
• SMILES: O=C(NC1=CC=C(Cl)C=C1)CN2N=C(C=3C=CC(Cl)=CC3)C=4C=CC=CC4C2=O
• Target: PARP
• Solubility: DMSO:5 mg/mL (11.78 mM)

Bioactivity

• Target IC50:
  PARP1:302 μM
• In Vitro:
  PARP-1-IN-4 exhibits inhibitory activity against PARP-1, with an IC50 value of 302 μM. It demonstrates cytotoxicity against A549 cells at concentrations of 0.1, 1, and 10 μM for 24h and 48h. Treatment with PARP-1-IN-4 at 1 μM for 24h significantly increases the expression levels of caspase-3 and caspase-9 proteins.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP1

Compound Identifiers

PubChem CID

1830002