PARP-1-IN-2

SKU: orb1687760

Description

PARP-1-IN-2 is a brain-penetrant, potent PARP1 inhibitor (IC50 = 149 nM). It demonstrates significant antiproliferative and pro-apoptotic activity against A549 lung adenocarcinoma cells in vitro, supporting its utility in oncology research for studying DNA damage response and cancer cell death mechanisms.

Research Area

Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 684234-55-7
• MW: 424.28
• Purity: 99.32% (May vary between batches)
• Formula: C₂₂H₁₅Cl₂N₃O₂
• SMILES: Clc1ccc(cc1)-c1nn(CC(=O)Nc2cccc(Cl)c2)c(=O)c2ccccc12
• Target: Apoptosis,Caspase,PARP
• Solubility: 10% DMSO+90% Corn Oil:0.5 mg/mL (1.18 mM);DMSO:9 mg/mL (21.21 mM)

Bioactivity

• Target IC50:
  PARP1:149 ± 11.0 nM
• In Vitro:
  PARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) exhibits significant anti-proliferative activity against A549 cells without notable cytotoxicity on HFF cells. PARP-1-IN-2 (0-10 μM, 24 h) reduces pro-caspase-3 and phosphorylated AKT expression, while increasing caspase-3, caspase-9 protein, and cleaved PARP-1 expression.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PARP1

Compound Identifiers

PubChem CID

1987353