Parmodulin 2

SKU: orb1307220

Description

Parmodulin 2

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 423735-93-7
• MW: 361.23
• Purity: 99.95%
• Formula: C₁₇H₁₇BrN₂O₂
• SMILES: CCCC(=O)Nc1cccc(NC(=O)c2ccccc2Br)c1
• Target: Protease-activated Receptor
• Solubility: DMSO:36.1 mg/mL (99.94 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.54 mM);Ethanol:36.1 mg/mL (99.94 mM)

Bioactivity

• Target IC50:
  PAR1:0.26 μM
• In Vivo:
  Through P-selectin expression assays, ML-161 has been found to inhibit thrombin-induced platelet activation in a dose-dependent manner. ML-161 selectively inhibits platelet aggregation induced by SFLLRN and thrombin through PAR1 (proteinase-activated receptor 1), without affecting platelet aggregation triggered by AYPGKF, thromboxane, or ADP (adenosine diphosphate).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

aggregation, ML 161, ML161, ML-161, Parmodulin 2, Parmodulin2, Parmodulin-2, PAR-1, PAR1, inhibit, Inhibitor, formation, P-selectin, Protease Activated Receptor (PAR), ProteaseactivatedReceptor, Proteaseactivated Receptor, Protease-Activated Receptor (PAR), protease-activated, platelet, Thrombin receptors, thrombus, receptor, SFLLRN-induced

Compound Identifiers

PubChem CID

1048267