Pargyline hydrochloride

SKU: orb1225358

Description

Pargyline hydrochloride is an irreversible inhibitor of monoamine oxidase (MAO) that is used clinically to treat moderate hypertension.

Key Properties

• CAS Number: 306-07-0
• MW: 195.69
• Purity: >98% (HPLC)
• Formula: C₁₁H₁₄NCl
• SMILES: CN(CC#C)CC1=CC=CC=C1.Cl
• Target: MAO
• Solubility: DMSO: 38 mg/mL

Bioactivity

• In Vitro:
  Cell Proliferation Assay Cell line: LNCaP-LN3 cells. Concentration: 0.5 mM, 1 mM, 1.5 mM or 2 mM Incubation time: 24 hours, 48 hours, 72 hours, 96 hours or 120 hours. Result: Inhibited the proliferation of prostate cancer cells in a time- and dose-dependent manner. Cell Cycle Analysis Cell line: LNCaP-LN3 cells. Concentration: 0.5 mM, 2 mM Incubation time: 24 hours, 48 hours. Result: The S phase ratio of the cells was decreased, while their G1 phase ratio was increased. Apoptosis Analysis Cell line: LNCaP-LN3 cells. Concentration: 0.5 mM Incubation time: 24 hours. Result: Increased the apoptotic cells. Western blot analysis. Cell line: LNCaP-LN3 cells. Concentration: 2 mM. Incubation time: 48 hours. Result: Induced an increase of cytochrome c and a decrease of caspase-3.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 43798

Quick Database Links

Gene Symbol

MAO