PAR-2-IN-2

SKU: orb2945441

Description

PAR-2-IN-2 (P-596) is a selective small molecule antagonist of protease-activated receptor 2 (PAR-2), inhibiting the SLIGKV peptide with an IC50 of 10.79 µM while showing significantly weaker activity against trypsin (IC50 >200 µM). This compound is a valuable research tool for studying PAR-2-mediated signaling in inflammation, pain, and cancer research using in vitro cellular assays.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 313986-65-1
• MW: 479.454
• Formula: C₂₅H₂₀F₃N₅O₂
• SMILES: O=C(C1=NN2C(N=C(C=C2C(F)(F)F)C=3C=CC=CC3)=C1)N4CCN(C(=O)C=5C=CC=CC5)CC4
• Target: Serine Protease,Protease-activated Receptor

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

1100830