PAP-1

SKU: orb1296152

Description

PAP-1

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 870653-45-5
• MW: 350.36
• Purity: 99.75%
• Formula: C₂₁H₁₈O₅
• SMILES: O=c1ccc2c(OCCCCOc3ccccc3)c3ccoc3cc2o1
• Target: Potassium Channel
• Solubility: DMSO:50 mg/mL (142.71 mM);H2O:Insoluble;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.71 mM)

Bioactivity

• Target IC50:
  Kv1.5 channel:45 nM (EC50)|Kv1.3 channel:2 nM (EC50)
• In Vivo:
  PAP-1 (0.3-3 mg/kg; i.p.; thrice daily for 48 hours) prevents delayed type hypersensitivity (DTH) in Lewis rats.
• In Vitro:
  PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state o the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50: 45 nM), and further displays 33- to 125-fold selectivity over All Other Kv1-family channels [1, 2]. PAP-1 (2-100 nM; 30 minutes) suppresse the proliferation of CCR7-TEM cells IC50 10 nM).
• Cell Research:
  Cell Line: CCR7-TEM cells (anti-CD3 Ab stimulated). concentration 2, 10, 25, 100 nM. Incubation Time: 30 minutes
• Animal Research:
  Animal Model: 9- to 11- week-old f Male Lewis rats. Dosage: I.P.; three times daily for 48 hours. Administration: 0.3, 1, 3 mg/kg

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

5-(4-Phenoxybutoxy)psoralen, Inhibitor, PAP 1, PAP-1, PAP1, KcsA, Kv1.3 channels, inhibit, Potassium Channel, PotassiumChannel

Compound Identifiers

PubChem CID

11302540