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Pantothenate Kinase Inhibitor

SKU: orb1693046

Description

PANKi is a potent, reversible inhibitor of pantothenate kinase isoforms, the rate-limiting enzyme in CoA biosynthesis. It exhibits mixed-type inhibition and, at low micromolar concentrations, inhibits cellular CoA production and synergizes with compounds like BSO to induce ferroptosis in cancer cell lines, providing a research tool for studying metabolism and cell death.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number902614-04-4
MW391.49
FormulaC21H21N5OS
SMILESCSc1cccc(NC(=O)CCc2c(C)nc3c4cccnc4nn3c2C)c1
TargetOthers

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information