Pantoprazole sodium hydrate

SKU: orb1225998

Description

A proton pump inhibitor that inhibits gastric acid secretion; works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid; inhibits autophagy and increases the toxicity of docetaxel in vitro and in vivo.Ulcer Approved.

Key Properties

• CAS Number: 164579-32-2
• MW: 433.38
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₅F₂N₃O₄S . 3/2H₂ O . Na
• SMILES: O.O.O.[Na+].[Na+].COC1=C(OC)C(CS(=O)C2=NC3=C([N-]2)C=CC(OC(F)F)=C3)=NC=C1.COC1=C(OC)C(CS(=O)C2=NC3=C([N-]2)C=CC(OC(F)F)=C3)=NC=C1
• Target: Proton Pump
• Solubility: 10 mM in H2O

Bioactivity

• In Vivo:
  Pantoprazole sodium hydrate (BY1023 sodium hydrate; 200 mg/kg; IP; once a week for 3 weeks) significantly increases tumor growth delay of MCF-7 xenografts combined with Doxorubicin. Pantoprazole sodium hydrate (0.3-3 mg/kg, p.o.) dose-dependently decreases both basal acid secretion in pylorus-ligated rats and the stimulated acid secretion induced by mepirizole in acute fistula rats. Animal model: Mice bearing MCF-7 or A431 xenografts. Dosage: 200 mg/kg. Administration: IP; once a week for 3 weeks; alone or 2 hours before Doxorubicin (6 mg/kg i. v.). Result: Showed even greater growth delay of MCF-7 xenografts with Doxorubicin compared with the single-dose combination. Significantly increased tumor growth delay with a single dose with Doxorubicin.
• In Vitro:
  Pantoprazole sodium hydrate (BY1023 sodium hydrate; 1-10000 μM) leads to concentration-dependent increases in endosomal pH in EMT-6 and MCF7 cells. Pantoprazole sodium hydrate can block exosome release. Pantoprazole sodium hydrate inhibits the activity of V-H+-ATPase and impaires the ability of tumour cells (melanomas, adenocarcinomas, and lymphoma cell lines) to acidify the extracellular medium.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SKF-96022 sodium hydrate

Quick Database Links

Gene Symbol

Proton Pump