Panitumumab

SKU: orb1219973

Description

Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).

Key Properties

• CAS Number: 339177-26-3
• MW: 147 kDa
• Purity: >98% (HPLC)
• Formula: ——
• Target: EGFR

Bioactivity

• In Vivo:
  Animal model: NCI-H1975 and NCI-H1650 xenografts. Dosage: 25, 100, or 500 μg/mouse. Administration: Intraperitoneal injection (i.p.), twice a week. Result: Inhibited ligand-induced EGFR phosphorylation, tumor growth, and markers of proliferation. Decreased Ki-67 and phospho-mitogen-activated protein kinase (pMAPK) staining in both xenografts.
• In Vitro:
  Western blot analysis. Cell line: EGFR-expressing NCI-H1975 cells, NCI-H1650 cells and CHO cells. Concentration: 2, 20, 200, 2000 nM. Incubation time: 3 h. Result: Inhibited ligand-induced autophosphorylation of EGFR.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR