Panduratin A

SKU: orb1695758

Description

Panduratin A is a bioactive chalcone with demonstrated in vitro activity against cancer cell lines (KB, PC-3, DU-145) and Dengue virus NS3 protease. It also modulates metabolic pathways by activating the LKB1-AMPK-PPARα/δ axis, enhancing mitochondrial oxidative capacity in muscle cells.

Research Area

Cell Biology, Epigenetics & Chromatin, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Protein Biochemistry, Signal Transduction

Key Properties

• CAS Number: 89837-52-5
• MW: 406.51
• Purity: 99.58% (May vary between batches)
• Formula: C₂₆H₃₀O₄
• SMILES: C(=O)([C@H]1[C@@H](CC=C(C)[C@H]1CC=C(C)C)C2=CC=CC=C2)C3=C(O)C=C(OC)C=C3O
• Target: MMP,Virus Protease,Antibacterial,AMPK,Apoptosis,PPAR

Bioactivity

• Target IC50:
  A549 cells:6.26 μM|H1299 cells:4.73 μM|Calu-1 cells:3.98 μM
• In Vivo:
  In A549 xenograft-bearing mice, oral administration of Panduratin A at 25 mg/kg once daily for 14 days significantly suppressed tumor growth by approximately 55% without affecting body weight or causing observable toxicity. Tumor tissues showed increased Bax, decreased Bcl-2, and enhanced cleaved caspase-3 expression, confirming its pro-apoptotic mechanism.
• In Vitro:
  Panduratin A exhibited potent antiproliferative effects in multiple human lung cancer cell lines (A549, H1299, Calu-1), with IC₅₀ values after 72 hours of treatment being 6.26, 4.73, and 3.98 μM, respectively. In A549 cells, Panduratin A (2.5–10 μM) induced dose-dependent apoptosis, G0/G1 arrest, mitochondrial membrane depolarization, and increased ROS levels within 48 hours. Panduratin A also suppressed activation of PI3K/AKT and MAPK pathways.

Storage & Handling

• Storage: store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Panduratin A

Compound Identifiers

PubChem CID

6483648