pan-TEAD-IN-1

SKU: orb2814227

Description

pan-TEAD-IN-1 is a potent, orally bioavailable pan-TEAD inhibitor that blocks YAP/TAZ coactivator binding by targeting TEAD palmitoylation. It effectively suppresses downstream oncogenes (e.g., Ctgf, Cyr61) in vitro and demonstrates significant anti-tumor activity in TEAD-dependent cancer xenograft models, making it a valuable research tool for Hippo pathway and oncology studies.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 3027484-09-6
• MW: 331.33
• Formula: C₁₉H₁₆F₃NO
• SMILES: O=C(C=C)N1CC=2C=C(C=CC2CC1)C3=CC=C(C=C3)C(F)(F)F
• Target: YAP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

170736102