pan-Raf/RTK inhibitor 1

SKU: orb2945932

Description

Compound I-16 is a potent pan-Raf inhibitor with low nanomolar IC50 values against BRafV600E, ARaf, BRafWT, and CRaf. It demonstrates antiproliferative effects in cancer cell lines and is a valuable tool for investigating Raf-driven signaling in both in vitro and in vivo cancer research models.

Research Area

Neuroscience; Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 1980821-53-1
• MW: 579.573
• Formula: C₂₉H₂₈F₃N₇O₃
• SMILES: O=C(NC1=CC=C(C(=C1)C(F)(F)F)CN2CCOCC2)C3=CC=C(C(=C3)NC(=O)C4(C5=NC=NC=6N=CNC65)CC4)C
• Target: Raf

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171378851