pan-KRAS-IN-6

SKU: orb2564692

Description

Pan-KRAS-IN-6 (compound 12) is a high-potency pan-KRAS inhibitor, demonstrating single-digit nanomolar IC50 values against the G12D (9.79 nM) and G12V (6.03 nM) oncogenic mutants. This small molecule is a valuable research tool for investigating KRAS-driven cancers in both cellular and animal model systems.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 3033565-36-2
• MW: 635.10
• Formula: C₂₉H₃₀ClF₃N₆O₃S
• SMILES: C(OC=1N=C(C2=C(N1)C(F)=C(C(Cl)=C2)C3=C4C(SC(N)=N4)=C(F)C=C3)N5CC(C)(O)COCC5)[C@@]67N(C[C@H](F)C6)CCC7
• Target: Ras,Kras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171102321