pan-KRAS-IN-18

SKU: orb3173467

Description

pan-KRAS-IN-18 (Compound 14-1) is a broad-spectrum KRAS inhibitor. It demonstrates potent antitumor activity, significantly inhibiting the proliferation of both wild-type and mutant cancer cells, such as KRASG12D, KRASG12V, and KRASG12C. Additionally, pan-KRAS-IN-18 effectively suppresses tumor growth in xenograft mouse models like GP2D and Panc0403.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3024881-00-0
• MW: 749.24
• Formula: C₃₆H₃₉ClF₄N₈O₃
• SMILES: C(OC1=NC(=C2C(=N1)C[C@H](OC2)C3=C(C(F)(F)F)C(C#CC)=CC(N)=C3F)N4CC=5N(CCC4)N=C(C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C5Cl)[C@@]67N(CC(=C)C6)CCC7
• Target: Ras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ras