PAβN dihydrochloride

SKU: orb1309278

Description

PAβN dihydrochloride, also known as MC-207,110 dihydrochloride, is a well-characterized efflux pump inhibitor. It is widely used in microbiological research to study multidrug resistance mechanisms and to potentiate antibiotic efficacy in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 100929-99-5
• MW: 519.47
• Purity: 99.87%
• Formula: C₂₅H₃₂Cl₂N₆O₂
• SMILES: Cl.Cl.N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)Nc1ccc2ccccc2c1
• Target: Antibacterial
• Solubility: DMSO:95 mg/mL (182.88 mM);H2O:14.29 mg/mL (27.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.35 mM)

Bioactivity

• In Vitro:
  PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates.

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, inhibit, PAbN, PAbN Dihydrochloride, PAbetaN, PAbetaN Dihydrochloride, PAβN, PAβN dihydrochloride, PAβN Dihydrochloride, MC-207,110, MC-207,110 Dihydrochloride, MC-207,110 dihydrochloride, Inhibitor, efflux pump, Phe-Arg-beta-naphthylamide, Phe-Arg-beta-naphthylamide Dihydrochloride, Phe-Arg-b-naphthylamide, Phe-Arg-β-naphthylamide dihydrochloride, Phe-Arg-β-naphthylamide, Phe-Arg-β-naphthylamide Dihydrochloride, Phe-Arg-b-naphthylamide Dihydrochloride

Compound Identifiers

PubChem CID

90665180