Pamoic acid disodium

SKU: orb2901467

Description

Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect.

Key Properties

• CAS Number: 6640-22-8
• MW: 411.36
• Purity: >98% (HPLC)
• Formula: C₂₃H₁₆NaO₆
• SMILES: [Na+].[Na+].Oc1c(cc2ccccc2c1Cc1c(O)c(cc2ccccc12)C([O-])=O)C([O-])=O
• Solubility: In Vitro: DMSO : 100 mg/mL (231.30 mM; Ultrasonic (<60°C)

Bioactivity

• In Vivo:
  Animal model: Swiss-Webster mice (30–35 g). Dosage: 25, 50, and 100 mg/kg. Administration: Subcutaneous injection, once. Result: Elicited dose-related antinociception, the dose causing 50% antinociception being 40.5 mg/kg.
• In Vitro:
  Western blot analysis. Cell line: U2OS cells. Concentration: 1, 10, 100 nM and 1, 10 μM. Incubation time: 15 min. Result: A concentration-dependent activation of ERK1/2 was observed with an EC50 of 65 nM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only