palovarotene

SKU: orb1223129

Description

Palovarotene, also known as RO-3300074 and R-667, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema. Phase I clinical trials of palovarotene in patients with emphysema demonstrated that the drug is well tolerated, with improvements observed in markers of emphysema progression. Emphysema is characterized by the destruction of alveoli and alveolar ducts within the lungs. Retinoid signaling is believed to play a role in alveologenesis, with the retinoic acid receptor gamma thought to be required for alveolar formation.

Key Properties

• CAS Number: 410528-02-8
• MW: 414.55
• Purity: >98% (HPLC)
• Formula: C₂₇H₃₀N₂O₂
• SMILES: O=C(O)c1ccc(cc1)/C=C/c3cc4c(cc3Cn2cccn2)C(C)(C)CCC4(C)C
• Target: c-Met/HGFR
• Solubility: DMSO : 19.5 mg/mL. 47.04 mM

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RO-3300074 | RO 3300074 | RO3300074 | R-667

Quick Database Links

Gene Symbol

c-Met/HGFR